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In this ongoing household cohort study in Nicaragua, previous SARS-CoV-2 infection during a second Covid-19 wave provided some protection against symptomatic Covid-19, with greater protection against severe illness.

Correspondence Protection from Previous SARS-CoV-2 Infection H.E.

Tan and Othersĭata from Singapore on BNT162b2 vaccination in children 5 to 11 years of age showed that during a period of omicron-variant predominance, BNT162b2 reduced the risks of SARS-CoV-2 infection and Covid-19–related hospitalization.

Original Article BNT162b2 Protection against Omicron in Children S.H.X.

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This phase 2 trial of an agent targeting SERPINA1 messenger RNA showed a reduction in levels of mutant AAT protein in affected persons. Mutant AAT protein accumulates in the liver and can lead to liver disease. Severe AAT deficiency is caused by a mutation in SERPINA1, which encodes AAT. Original Article Treatment of Severe Alpha 1-Antitrypsin Deficiency P.

Aug 11Įditorial Preemptive Removal of Small, Asymptomatic Kidney Stones Removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral stones resulted in less relapse than nonremoval and in similar numbers of subsequent emergency department visits.

Original Article Removal of Small Kidney Stones and Relapse M.D.

Opportunities exist to expand the distribution, use, and oversight of effective medication. Many children born with sickle-cell disease in sub-Saharan Africa will die before their fifth birthday.

Perspective Bringing Sickle-Cell Treatments to Sub-Saharan Africa A.E.

It’s now feasible to track, for each patient seen at a health care facility, which Covid-19 vaccine they received when and what their clinical evaluation revealed.

Perspective Understanding Covid Vaccine Efficacy over Time I.

Practices should recognize the changing legal landscape and adjust their employment contracts accordingly. Recent developments in health care delivery pose challenges for noncompete agreements. Litigation related to Covid-19 treatment guidance in New York highlights these issues. JostĮxplicitly including race or ethnicity as a factor in government allocation of resources raises legal concerns.

Perspective Race and Ethnicity in Covid Risk Assessments T.S.

This interactive feature about screening for atrial fibrillation in asymptomatic older adults offers a case vignette accompanied by two essays, one supporting screening and the other supporting deferral of screening.

Clinical Decisions Screening for AF in Asymptomatic Older Adults C.

In this audio interview conducted on August 9, the editors discuss the shifting benefits of preventive and therapeutic interventions against Covid-19 and what the future might bring. Aug 11Ĭombating Covid-19 Today and Tomorrow E.J. In this phase 1–2 study involving patients with relapsed or refractory myeloma, a bispecific antibody (teclistamab) that mediates T-cell activation and subsequent lysis of myeloma cells expressing B-cell maturation antigen induced responses in 63% of the patients, including a complete response in nearly 40%.

Original Article Redirecting T Cells against Myeloma Cells P.

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Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills.

Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.